WebFollicular helper T (Tfh) cells are a unique CD4 + T cell subset to initiate germinal center (GC) formation and promote B cell responses, which are essential for the production of high-affinity antibodies to eliminate invading pathogens ( Crotty, 2011; Vinuesa et al., 2016 ). Web21 Mar 2014 · Our study reveals that circulating TFH cells may be involved in HBV-related immune responses via transcription factors in combination with induction signals and secreted cytokines. We further clarify the relationship between circulating TFH cells and clinical parameters in patients with chronic HBV infection.
Tfh cells set the stage for tumor control - Immunity
Web8 Dec 2024 · On the basis of lineage commitment, they are classified into plasmacytoid DCs, monocyte-derived DCs, and conventional/classical DCs (cDCs) ; the latter group of cells uniquely express the transcription factor Zbtb46 and are primarily responsible for naïve T cell activation and Tfh cell induction (8, 9). cDCs can be further divided into two subsets … Web10 May 2024 · Follicular helper T (Tfh) cells play a key role in driving B cell activation and differentiation during germinal center reactions in immune responses and autoimmune development, and these cells... chicago o\\u0027hare duty free
Frontiers Providing a Helping Hand: Metabolic Regulation of T ...
Web16 Oct 2014 · Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development … Web13 Mar 2013 · Follicular helper (Tfh) CD4 T cells are a subset of differentiated CD4 T cells that express CXCR5, the chemokine receptor for B cell homing chemokine CXCL13 ( 1 ). Surface CXCR5 expression enables Tfh cells to migrate into B cell follicles, where they provide help to B cells to form germinal centers ( 2 ). WebT-follicular-helper (Tfh) and recently described pathogenic peripheral-helper T-cells (Tph) are key mediators in (autoreactive) B-cell differentiation through inducible T-cell costimulator … chicago o\u0027hare economy parking