Spi1 and cancer
WebDec 7, 2024 · SPI1 was an independent prognostic factor for poor overall survival and progression-free survival in patients with ccRCC. SPI1 expression was strongly related to the infiltration of immune cells and immune-related molecules. SPI1 was more highly expressed in tumor-infiltrating immune cells rather than in cancer cells. WebApr 1, 2024 · In breast cancer, lung cancer and cervical cancer, SPI1 plays a role in promoting cancer . In glioma, results have shown that SPI1 plays a cancer-promoting role [30, 31], but the functional verification and mechanism of SPI1 have not yet been reported. In this study, we investigated expression, function and mechanism of SPI1 in glioma.
Spi1 and cancer
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http://www.cancerindex.org/geneweb/SPI1.htm WebNov 15, 2024 · The expression of SPI1 was increased significantly in gastric cancer according to multiple databases, and high expression of SPI1 was related to poor prognosis of patients with gastric cancer [7]. Moreover, SPI1 could activate the transcription of SNHG6, thereby promoting the progression of non-small cell lung cancer [8].
WebAug 1, 2015 · Sp1 plays a major role in the regulation of the expression of the vascular endothelial growth factor (VEGF) in a variety of tumors, and several different strategies …
WebJan 22, 2024 · Results. Signal transducer and activator of transcription 3 (STAT3) and Spi-1 proto-oncogene (SPI1) was identified as the hub genes in the datasets GSE73754.And the t-test showed that the expression level of STAT3 and SPI1 in the GSE73754 was significantly higher in AS and human leukocyte antigen (HLA)-B27(+) groups. Flow cytometric analysis … WebDec 14, 2024 · First, we used a Cox regression analysis to estimate the association between the expression of all DEGs and the overall survival time of patients. Tumor samples were grouped into the “high expression group” and “low expression group” with the median gene expression level set as the cutoff.
http://mdedge.ma1.medscape.com/hematology-oncology/article/184611/leukemia-myelodysplasia-transplantation/evi1-overexpression-promotes
WebWe showed that SPI1, PRDX2, DLEC1, KLF4 and DAPK1 genes are epigenetically silenced via hypermethylation in the tumor tissues of children with HL and NHL. As CDKN2A gene … tally rameshWebNational Center for Biotechnology Information two way street roadWebDec 12, 2024 · SPI1 serves as a downstream effector of PRDM1 to enhance PD-L1 transcription. ... Functionally, T cell-mediated cancer cell-killing assays and subcutaneous and orthotopic models demonstrated that PRDM1 overexpression in HCC cells dampens T cell-induced cytotoxicity by upregulating tumoral PD-L1 expression. two way stretch filmWebJan 25, 2024 · SPI1, as the key transcription factor for the network, may shape a positive-feedback network with the signaling from TYROBP/FCER1G or environmental TNF-α/IFN-γ, … two way stretch 1960 filmWebApr 11, 2024 · The precision of TERT-based anti-cancer therapies will be crucial to overcome off-target side-effects, especially given the extra-telomeric functions of telomerase. ... SPI1) in human HL60 and U937 cells (neutrophil and monocyte progenitors) that relied on the recruitment of RNA polymerase II (García-Castillo et al., 2024). two way street widthWebJun 3, 2024 · SPI1 is an ETS family member that plays a crucial role in hematopoiesis ( 5–7 ), including at different steps of B-cell development, coordinating the proliferation and … two way stretch full movieWebTo characterize the interactions of non-small cell lung cancer (NSCLC) tumors with the immune system at the level of mRNA and microRNA (miRNA) expression and to define expression signatures that characterize the presence of a malignant tumor versus a nonmalignant nodule. ... ELK4, and SPI1 were enriched in promoter regions of genes … tallyrand industrial systems