Irf4 t cell

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August undefined, 2024

WebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ... WebJan 19, 2024 · IRF4 was severely down-regulated in the colon cancer tissues. Colon cancer tissues exhibited an increase in the number of regulatory T cells (Tregs) and macrophages. Furthermore, IRF4 overexpression repressed proliferation, migration and invasion of colon cancer cells (SW480 and HT116 cells).

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WebMar 9, 2024 · The IRF4-deficient T cells exhibit reduced capacity to induce expansion of T-helper subsets that cause autoimmune disease, suggesting that an intrinsic function of … WebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as … citing a figure

Phosphatidylserine-positive extracellular vesicles boost effector …

WebFeb 14, 2014 · The interferon regulatory factor 4 (IRF4) is an important immunological transcription factor required for B-cell maturation 3 and for the maintenance of various … WebSep 1, 2024 · Concept: Cooperation between BATF and IRF4 enhanced tumor inhibition and promoted memory T-cell formation. Impact: Countering T-cell exhaustion via induced … WebDec 23, 2024 · CD8+T cell exhaustion is a state of T cell dysfunction during chronic infection and tumor progression. Exhausted CD8+T cells are characterized by low effector function, high expression of inhibitory receptors, unique metabolic patterns, and altered transcriptional profiles. Recently, advances in understanding and interfering with the … citing a figure apa

Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A ...

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WebApr 11, 2024 · CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T cells; however, it remains unclear whether they can actively modulate CD8 + T cell responses. In this … WebIRF4 from CD8+ T cells after their activation. We show that IRF4 is differentially required for long-term survival of CD8+ mem-ory T cell subsets. In particular, maintenance of tissue-resident memory T cells appears to depend on IRF4. Upon reactivation, IRF4-deficient CD8+ memory T cells are strongly impaired in theirproliferation andcytokine ... citing a film harvardWebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked attention. One of the main drivers of T cell exhaustion is prolonged antigen presentation, a prerequisite … diathermanes

"WebNational Center for Biotechnology Information " - Irf4 t cell

Irf4 t cell

Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis …

WebWe found that IRF4 was promptly induced in T cells upon TCR signaling through the MEK1/2 pathway. IRF4 ablation in T cells resulted in progressive establishment of CD4 + T cell dysfunction and induced heart allograft acceptance in mice. The dysfunctional state of Irf4 −/− T cells was initially reversible by blocking programmed death-ligand 1 (PD-L1) and … WebMar 29, 2024 · In terms of T cell-related markers, the results showed that the expression levels of the transcriptional regulator TBX-21 (T-bet) and interferon regulatory factor 4 (IRF4) were significantly upregulated in peripheral blood of the patients in the EPL group (P < 0.05), whereas the expression levels of GATA binding protein 3 (GATA3) and ...

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WebAug 27, 2024 · TCR signal strength and PRN694 regulate-graded NF-κB activation within digitally NFAT1 and p-Erk active cells. ( A and B) Histograms depicting CD69 and IRF4 expression after 24 h ( A) or CellTrace Violet fluorescence after 48 h ( B) in OT-I cells stimulated with APCs plus 100 nM indicated peptide with or without 50 nM ITK/RLK … IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40. IRF4 can function either as an activating or an inhibitory transcription factor depending on its transcription

WebDec 19, 2024 · Tuning Irf4 Energizes Dysfunctional T Cells. The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2024) and Wu et al. (2024) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue … WebIRF4 Is Highly Induced in Graft-Infiltrating T Cells and Is Required for Heart Transplant Rejection IRF4 is a key transcription factor for translating TCR signaling into proper T cell responses ( Huber and Lohoff, 2014 ), but its role in T cell-mediated transplant rejection remains unclear.

WebApr 15, 2024 · In T cells, IRF4 controls expression of a large number of genes, including genes coding for T cell effector proteins, for enzymes in central metabolism pathways, and for transcription factors and regulatory … WebIRF4 Is Highly Induced in Graft-Infiltrating T Cells and Is Required for Heart Transplant Rejection IRF4 is a key transcription factor for translating TCR signaling into proper T cell …

WebApr 13, 2024 · Front. Cell. Dev. Biol. 2024, 9, 570451.（标注基金号81960239、82060244）论文3：Hua Fang#, Jianping Zhang* et al., Dexmedetomidine-up-regulated microRNA-381 exerts anti‐inflammatory effects in rats with cerebral ischaemic injury via the transcriptional factor IRF4. J. Cell. Mol.

WebJun 3, 2024 · Although the precise regulatory mechanisms at play for IRF4 in T cells have yet to be fully elucidated, levels of IRF4 have been shown to be higher in resting Th2 cells compared to Th1 and Th17 . Inquiries into the role of IRF5 in other immune cell types have revealed alternative roles for IRF4 outside that of direct transcriptional regulation. diathermiaWebSep 29, 2024 · Total human B cells from healthy donors were stimulated under conditions described in Figure 1A and analyzed by flow cytometry at days 3.5 and 6. Cells were pre-gated on FSC-A/FSC-W to identify singlets, on FSC-A/SSC-A to identify lymphocytes, and on IRF4/ Pax5 expression to identify the P1, P2, and P3 populations. diatherme thermodynamiqueWebT cell exhaustion is characterized by high expression of inhibitory receptors and widespread transcriptional and epigenetic alterations 4, 5, 7, 18, 19, but the mechanisms responsible for... citing a film in apaWebJul 16, 2024 · Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance and in the regulation of immune responses against pathogens and tumor cells. Treg cells consist of heterogeneous subsets that have distinct phenotypes and functions. Upon antigen … diathermeWebJan 20, 2024 · The transcription factor interferon regulatory factor 4 (IRF4) is critical for development of the immune system, especially B and T cells. The IRF4 International Consortium identified seven patients from six families with a combined immunodeficiency who harbored a recurrent heterozygous mutation in IRF4, p.T95R. diathermanous earthWebAug 28, 2024 · Recurrent somatic mutations in host genes have exposed the T-cell receptor pathway through nuclear factor κB to interferon regulatory factor 4 (IRF4) as an essential … citing a film chicago styleWebtranscription factors IRF4, BATF, and NFATc1 that drives T cell exhaustion and impairs memory T cell development. Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection: Immunity Skip to Main Content Login to your account Email/Username Password Show Forgot password? citing a film in text